Ever wondered why your eyes look different when you’re high? It turns out that there’s a scientific reason for it.

When your eyes dilate, the pupil – the black circle in the center of the eye – enlarges. The dilation of the pupil is an autonomic nervous system response that’s mediated by neurotransmitters like norepinephrine, acetylcholine, and dopamine.

So what does this have to do with being high? Well, when you smoke cannabis, the active ingredient THC binds to cannabinoid receptors in the brain. This alters neurotransmitter release, which can lead to changes in pupil size.

In short, your eyes dilate because of changes in neurotransmitter release that are caused by THC binding to cannabinoid receptors. This is why your eyes look different when you’re high.

Drugs That Cause Eye Dilation

Drugs that cause eye dilation include:

Cannabis

This is the most common cause of eye dilation. The active ingredient in cannabis, THC, binds to cannabinoid receptors in the brain and alters neurotransmitter release. This can lead to changes in pupil size.

Amphetamines

Amphetamines are a type of stimulant drug that increases alertness and energy. They work by increasing the release of neurotransmitters like dopamine and norepinephrine. Amphetamines can cause the pupils to dilate.

Ecstasy

Ecstasy is a type of drug that alters mood and perception. It works by affecting the release of neurotransmitters like serotonin and dopamine. Ecstasy can also cause the pupils to dilate.

Cocaine

Cocaine is a type of stimulant drug that increases alertness and energy. It works by blocking the reuptake of neurotransmitters like dopamine and norepinephrine. This can lead to increased levels of these neurotransmitters in the brain, which can cause the pupils to dilate.

How long does eye dilation last?

Eye dilation from cannabis typically lasts for around 30 minutes to an hour. However, the effects of other drugs that cause eye dilation, like amphetamines and ecstasy, can last for several hours. Cocaine usually causes a brief, intense feeling of euphoria followed by a period of depression. The effects of cocaine wear off after around 30 minutes to an hour.

Other Causes of Eye Dilation

In addition to drugs, there are other things that can cause your eyes to dilate. These include:

Bright light

The pupils will dilate in response to bright light in order to reduce the amount of light that enters the eye. This helps to protect the retina from damage.

Emotional arousal

The pupils will also dilate in response to emotional arousal. This is because the autonomic nervous system is activated during times of stress or excitement, which can lead to changes in pupil size.

Eye exams

Some eye exams, like those that measure intraocular pressure, involve shining a bright light into the eyes. This can cause the pupils to dilate.

So, why do your eyes dilate when you’re high? THC, the active ingredient in cannabis, binds to cannabinoid receptors in the brain and alters neurotransmitter release. This can lead to changes in pupil size. The effects of cannabis typically last for around 30 minutes to an hour. However, the effects of other drugs that cause eye dilation, like amphetamines and ecstasy, can last for several hours. These drugs work by affecting the release of neurotransmitters like dopamine and norepinephrine. cocaine usually causes a brief, intense feeling of euphoria followed by a period of depression. These are some of the causes of eye dilation. Emotional arousal and eye exams can also cause the pupils to dilate. So, if you’re wondering why your eyes look different when you’re high, now you know!